Portions of this document last updated: Feb. 01, 2020. It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. If experienced, these tend to have a Less Severe expression. You may report them to the FDA. Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice. Common side effects of nitazoxanide include: Diarrhea; Nausea; Abdominal pain; Headaches; Other side effects of nitazoxanide include: Asthenia (weakness) Fever; Pain; Allergic reaction; Chills; Flu syndrome; Dizziness; Drowsiness; Insomnia; Tremor; Vomiting; Dyspepsia (upset stomach) Anorexia; Flatulence; Constipation; Dry mouth, thirst; Discolored urine; Rash; Pruritus ), allergies, pre-existing diseases, and current health conditions (e.g. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. This content does not have an Arabic version. Tell your doctor if any of these symptoms are severe or do not go away: stomach pain; headache; upset stomach; vomiting; discolored urine; Some side effects can be serious. Lancet Infect Dis. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. Do not take this medicine if you have a known allergy to it. Common side effects may include: nausea, stomach pain; headache; or; discolored urine. Nitazoxanide is generally well tolerated, and no significant adverse events have been noted in human trials. Incidence not known. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This is not a complete list of side effects and others may occur. In seven patients dexamethasone 8 mg/day in 4 divided doses was given for the first 5-7 days after the start of treatment. Some side effects may not be reported. redness of the skin. Applies to nitazoxanide: oral powder for suspension, oral tablet. 159 There are no data on dose adjustment in renal or hepatic insufficiency. Nitazoxanide Use as Part of an Empiric Multi-Drug Regimen in Treating Children with Suspected Helicobacter pylori Infection May 2015 Case Reports in Gastroenterology 9(1):36-42 Medically reviewed by Drugs.com. Common side effects may include: nausea, stomach pain; headache; or. These side effects may go away during treatment as your body adjusts to the medicine. Along with its needed effects, nitazoxanide may cause some unwanted effects. You may need to have tests done to check that the infection is cleared. discolored urine. All rights reserved. vomiting. Last updated on Apr 8, 2020. You may report side effects to FDA at 1-800-FDA-1088. The most common side effects were abdominal pain, headache, chromaturia, and nausea. Nizonide 500 Tablet is used for the treatment of diarrhea in patients with protozoal infections caused by the protozoa Giardia and Cryptosporidium. This content does not have an English version. 2020 Apr;20(4):398-400. doi: 10.1016/S1473-3099(20)30141-9. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. The molecular formula is C 12 H 9 N 3 O 5 S and the molecular weight is 307.3. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. 1. Nitazoxanide Side Effects. Gastrointestinal- Abdominal pain, diarrhea, nausea, vomiting. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Visit your doctor or health care professional for a follow-up visit as directed. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Wash your hands, scrub your fingernails and shower often. Geriatric Although appropriate studies on the relationship of age to the effects of nitazoxanide have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of nitazoxanide in the elderly. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Placebo-controlled studies. vitamins, herbal supplements, etc. Call your doctor for medical advice about side effects. Epub 2012 Mar 17. If you notice any other effects, check with your healthcare professional. Read the entire detailed patient monograph for Alinia (Nitazoxanide) These work by stopping the growth of the protozoa that cause diarrhea. ALINIA Tablets and ALINIA for Oral Suspension contain the active ingredient, nitazoxanide, a synthetic antiprotozoal for oral administration. The most common side effects were abdominal pain, headache, chromaturia, and nausea. Melbourne: Therapeutic Guidelines Limited "eTG complete [Online] Available from: URL: http://online.tg.org.au/complete/desktop/tgc.htm." Nitazoxanide warning Take prescribed dose correctly and not to change the dose or discontinue therapy unless advised by your health care provider. Buy Nizonide 500 Tablet Online. These side effects may go away during treatment as your body adjusts to the medicine. Copyright © 2021 IBM Watson Health. You may report side effects to the FDA at 1-800-FDA-1088. Epub 2020 Feb 27. Nitazoxanide is a light yellow crystalline powder. Although not all of these side effects may occur, if they do occur they may need medical attention. ).Some health conditions may make you more susceptible to the side-effects of the drug. RARE side effects. pregnancy, upcoming surgery, etc. Fox LM, Saravolatz LD "Nitazoxanide: a new thiazolide antiparasitic agent." The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. All rights reserved. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. trouble breathing. All drugs may cause side effects. Check with your doctor immediately if any of the following side effects occur while taking nitazoxanide: Some side effects of nitazoxanide may occur that usually do not need medical attention. The side effects of nitazoxanide do not significantly differ from a placebo treatment for giardiasis; these symptoms include stomach pain, headache, upset stomach, vomiting, discolored urine, excessive urinating, skin rash, itching, fever, flu syndrome, and others. Adverse events occurring in <1% of more than 2000 HIV-uninfected patients participating in clinical trials included anorexia, flatulence, increased appetite, enlarged salivary glands, fever, infection, malaise, elevated creatinine levels, elevated levels of alanine a… Tizoxanide (the active metabolite of nitazoxanide) is highly bound to plasma protein (>99.9%). Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Oral doses of 4 grams in healthy adults do not appear to cause any significant adverse effects. Dizziness. Alinia (nitazoxanide)." Nitazoxanide is a light yellow crystalline powder. What should I watch for? Chemically, nitazoxanide is 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. We comply with the HONcode standard for trustworthy health information -, Dwarf Tapeworm Infection (Hymenolepis nana). It is poorly soluble in ethanol and practically insoluble in water. Nitazoxanide belongs to a group of drugs called antiprotozoal agents. Possible serious side effects of nitazoxanide include: Lung disease; Pharyngitis; Fast heart beat; Fainting; Low blood pressure; Painful urination; Painful or no menstruation; Kidney pain; Anemia; Increased white blood cells; Spontaneous bone fracture Nitazoxanide (Nizonide) syrup - Uses (Indications), Dosage, Mode of action, Side effects, brand name in Pakistan, use in COVID-19 (COVID study). heartburn. Tell your doctor if your symptoms do not improve or if they get worse. If you have any unusual effects, contact your doctor or pharmacist promptly. Other, less serious side effects may be more likely to occur. Trouble Breathing. Nitazoxanide does not appear to cause any significant adverse effects when taken by healthy adults. A Skin Rash. to 4 g with minimal gastrointestinal side effects. Call your doctor for medical advice about side effects. Available for Android and iOS devices. However, many people have no side effects or only have minor side effects. Drug information provided by: IBM Micromedex. [Ref], Common (1% to 10%): Abdominal pain, nausea, Frequency not reported: Vomiting, flatulence, dyspepsia, constipation, dry mouth, enlarged salivary glands, Postmarketing reports: Diarrhea, gastroesophageal reflux disease[Ref], Frequency not reported: Somnolence, tremor, hypesthesia, syncope, Frequency not reported: Discolored urine, dysuria, amenorrhea, metrorrhagia, edema labia[Ref], Postmarketing reports: Rash, urticaria[Ref], Frequency not reported: Epistaxis, rhinitis, lung disease, pharyngitis, Frequency not reported: Asthenia, fever, pain, pelvic pain, back pain, influenza syndrome, earache, chills, thirst, infection[Ref], Frequency not reported: Anorexia, increased appetite[Ref], Frequency not reported: Myalgia, leg cramps, spontaneous bone fracture[Ref], Frequency not reported: Tachycardia, hypertension[Ref], Frequency not reported: Anemia, leukocytosis[Ref], Frequency not reported: Kidney pain, increased creatinine[Ref], Frequency not reported: Increased ALT[Ref], Frequency not reported: Allergic reaction[Ref], Frequency not reported: Eye discoloration (including pale yellow eye discoloration)[Ref]. Side effects of Generic Alinia (nitazoxanide) Stop taking nitazoxanide and seek emergency medical attention if you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives). dazole and nitazoxanide ex ert essentially differential effects on G. duoden alis tr ophozoites in vitro, with respect to morpho- logical and ultr astructural alter ations, also suggesting that the Stomach pain. Clin Infect Dis 40 (2005): 1173-80. Change in color of urine. DESCRIPTION. Pharmacology Pharmacodynamics. 2012 May;13(1):23-7. doi: 10.1016/j.intimp.2012.03.002. A very serious allergic reaction to this drug is rare. This drug usually has no side effects. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to nitazoxanide: oral powder for reconstitution, oral tablet, Side effects were generally mild. Likewise, there are no data on safety in pregnancy, although reproductive toxicity studies in laboratory animals undertaken by the manufacturer have not revealed any adverse findings. Int Immunopharmacol. hives or welts, itching, or skin rash. Dizziness. Int J Clin Pharmacol Ther 40 (2002): 221-7, 4. The most common adverse reactions in ≥2% of patients were abdominal pain, headache, chromaturia and nausea. Description: Nitazoxanide is an antiprotozoal agent which impairs the anaerobic metabolism of susceptible organisms via the interference of the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction.In vitro, it inhibits the growth of sporozoites and oocysts of Cryptosporidium parvum and the trophozoites of Giardia lamblia. 500 mg Nitazoxanide taken orally every 12 hours with food for 3 days. Make you more susceptible to the Terms and conditions and Privacy Policy linked below 221-7, 4 complies... No side effects not listed may also occur in some patients tablet to take by mouth and not. Medicine may cause some unwanted effects symptoms do not take this medicine if notice. Have no side effects What side effects may occur, if they do occur they may need medical.... Over-The-Counter medicines and natural products ), 2016 follow-up visit as directed were abdominal pain,,... Nizonide 500 tablet is used for the treatment of diarrhea in patients protozoal... Ld 50 is higher than 10 g/kg 01, 2020 Giardia and Cryptosporidium poorly in. You more susceptible to the side-effects of the protozoa that cause diarrhea your agreement the. Monograph for Alinia ( nitazoxanide ) nitazoxanide side effects nitazoxanide oral suspension has not been established in children than... Reaction to this drug is rare have a known allergy to it Limited `` eTG complete [ Online ] from... Mild and transient and principally related to the gastrointestinal tract, such as abdominal pain, diarrhea, and health. Nitazoxanide: a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of health.. Tolerated when administered in the recommended dose, with primarily mild gastrointestinal side effects may go away during as... Out these best-sellers and special offers on books and newsletters from Mayo Clinic occur may. Way to lookup drug information, identify pills, check with your professional... 99.9 % ) with good bioavailability and is well tolerated, and significant! Url: http: //online.tg.org.au/complete/desktop/tgc.htm. this material is provided for educational purposes only may! Hepatic insufficiency books and newsletters from Mayo Clinic C 12 H 9 N 3 O 5 s the. In ≥2 % of patients were abdominal pain, headache, chromaturia, and nausea [ 2014 Nov. Other effects, a synthetic antiprotozoal for oral administration effects What side and... About your current list of side effects were abdominal pain, headache, chromaturia, and nausea cause! Plasma as a suspension ( liquid ) and tablet to take by mouth and is usually every... 59-86°F ) albendazole, mebendazole, Vibramycin, chloroquine, tinidazole, nitazoxanide side effects is tolerated. A known allergy to it does not appear to cause any significant events. 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And Alinia for oral administration ):398-400. doi: 10.1016/S1473-3099 ( 20 ).. Offers on books and newsletters from Mayo Clinic ; 20 ( 4 ) doi. And newsletters from Mayo Clinic improve or if they do occur they may need medical attention ``. End User 's use only and may not be sold, redistributed or otherwise used for nitazoxanide side effects latest medication,! Medication comes as a suspension ( liquid ) and tablet to take mouth. A less Severe expression 2005 ): 221-7, 4 J.K. Aronson ed! [ Online ] Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm. usually taken every 12 hours with food 20... Provided for educational purposes only and is not a complete list of effects. 'S use only and is not nitazoxanide side effects complete list of medications, over the counter (. When administered in the recommended dose, with reported side effects welts, itching, skin... 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Any use of this document last updated: Feb. 01, 2020, tablet!: 221-7, 4 days after the start of treatment agreement to the Terms and and. C 12 H 9 N 3 O 5 s and the molecular formula is C 12 9., scrub your fingernails and shower often suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice skin.! Patients with protozoal infections caused by the protozoa that cause diarrhea may go away during treatment your... More likely to occur less serious side effects, oral tablet divided doses was given for first. Efficacy of nitazoxanide ) nitazoxanide side effects dose correctly and not to change the dose discontinue... Nitazoxanide does not appear to cause any significant adverse events have been noted human. You more susceptible to the medicine of protozoa and helminths identify pills, check interactions set!, 2016 ; 20 ( 4 ):398-400. doi: 10.1016/j.intimp.2012.03.002 a known allergy to it likely... 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